Dry mortar is widely used in the modern construction and decoration projects.Dry mortar is a kind of powder or granular mixture of quartz sand, inorganic cementitious materials,
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Using whole-exome sequencing to identify variants inherited from mosaic parents eur j hum genet 23, 547550 2015 29 contini, e et al a systematic assessment of accuracy in detecting somatic mosaic variants by deep amplicon sequencing application t...
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The clinical management of cancer has evolved in recent years towards more personalized strategies that require a comprehensive knowledge of the complex molecular features involved in tumor growth and evolution, and the development of drug resistance mech...
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2016-1-7detecting ultralow-frequency mutations by duplex sequencingscott r kennedy 1 , michael w schmitt 2 , edward j fox 1 , brendan f kohrn 3 , jesse j salk 2 , eun hyun ahn 1 , marc j prindle 1 , kawai j kuong 1 , jiang-cheng shen 1 , rosa-ana...
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2015-11-5detectingultralow-frequencymutationsbyduplexsequencingscottrkennedy1michaelwschmittedwardjfox1brendanfkohrn3jessejsalkeunhyunahn1marcjprindle1kawaijkuong1jiang...
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Kennedy, s r, et al detecting ultralow-frequency mutations by duplex sequencing nat protoc 9 a platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer t, et al noninvas...
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2020-1-31detecting ultralow-frequency mutations by duplex sequencing kennedy et al, nature protocols 92586-2606, 2014 snp discovery and allele frequency estimation by deep sequencing of reduced representation libraries van tassell, et al, nature method...
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Dr lawrence loeb is a pathologist in seattle, wa detecting ultralow-frequency mutations by duplex sequencing ultra-sensitive sequencing reveals an age-related increase in somatic...
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2020-2-3dr michael w schmitt is an oncologist in seattle, washington he received his medical degree from university of washington school of medicine and...
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Shotgun metagenomic sequencing is increasingly utilized as a tool to evaluate ecological-level dynamics of antimicrobial resistance and virulence, in conjunction with microbiome analysis interest in use of this method for environmental surveillance of an...
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It has been adopted by various sequencing methods such as duplex-seq kennedy et al, 2014 and ides newman et al, 2016 for illumina sequencing platforms, umi can be integrated into the sample index or inserted dna detecting ultralow-frequency mutati...
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2019-12-27targeted sequencing using a panel with hundreds of genes so the coverage in genome scale is very sparse, whereas the coverage in capturing regions is high and dense application since gencore can be used to reduce sequencing errors, it is very...
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Since gencore can be used to reduce sequencing errors, it is very useful for the application of detecting low-frequency somatic mutations from cancer sequencing data, particularly in liquid biopsy technology when the samples are from blood, urine or mal...
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Highlights from the 58th meeting of the american society of haematology, 16 december 2016, san diego, usa luca mazzarella european institute of oncology, via ripamonti 435, milan 20141, italy...
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Dnmt3ar882, tet2, asxl1, and srsf2 mutations identified at the time of diagnosis are associated with delayed count recoverypersistence of preleuke dna isolated from remission pb samples was performed using a custom 37-gene error-corrected ngs platfor...
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2019-10-24alternative designs based on truseq adapters either preclude duplex formation by annealing or require additional sequencing cycles or custom sequencing steps demonstrating that correctly identifying pcr duplicates is critical for quantifying...
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2019-10-24quantitative analysis of next-generation sequencing ngs data requires discriminating duplicate reads generated by pcr from identical molecules that are of unique origin detecting ultralow-frequency mutations by duplex sequencing nat e...
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We present here a simple, phenotype-independent mutation assay using a pacbio rsii dna sequencer employing single-molecule real-time smrt sequencing technology salmonella typhimurium yg7108 was treated with the alkylating agent n-ethyl-n-nitrosourea enu...
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Corrigendum detecting ultralow-frequency mutations by duplex sequencing nat protoc if 11334 pub date 2014 over the last decade, technical advances in nucleic acid sequencing and mass spectrometry have enabled faster and more informative...
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A plethora of approaches to detect mutations in plasma dna ranging from the focused analysis of a single mutation to panel sequencing to wholeexome sequencing have been described 24, 28, 30-37 metrics to quantify ctdna include the mutant allele fraction...
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2020-3-4malignant tumors shed dna into the circulation the transient half-life of circulating tumor dna ctdna may afford the opportunity to diagnose, monitor recurrence, and evaluate response to therapy solely through a non-invasive blood draw however,...
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Point mutations of the n-ras gene in the blood plasma dna of patients et al detecting ultralow-frequency mutations by duplex sequencing nat protoc 20149112586-2606 12 thierry ar, mouliere f, el messaoudi s, et al clinical validation of the c...
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Krimmel jd, schmitt mw , harrell mi, agnew kj, kennedy sr, emond mj, loeb la, swisher em, risques ra ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic tp53 mutations in non-cancerous tissues proc natl...
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Should i remove pcr duplicates from my rna-seq data the short and generalized answer to the question should i remove pcr duplicates from my rna-seq data is in most cases no for some scenarios, de-duplification can be helpful, but only when using umispl...
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26 keywords low-frequency mutation, unique molecular identi er, dna polymerase error, targeted se- 27 quencing, homopolymer, variant caller 28 1 introduction 29 detection of low-frequency variants is important for early cancer diagnosis and is a very acti...
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